TOLERANCE TO NITROGLYCERIN.
نویسندگان
چکیده
منابع مشابه
Nitroglycerin and Nitrate Tolerance
Background. The present study was designed to investigate the intracellular production of cyclic GMP (cGMP) in platelets in response to nitroglycerin and to determine the potential clinical value of platelet cGMP as an indicator of the effects of nitroglycerin and nitrate tolerance. Methods and Results. Platelet cGMP levels and the diameters of the coronary arteries before and 2 minutes after i...
متن کاملNitroglycerin tolerance in human vessels: evidence for impaired nitroglycerin bioconversion.
BACKGROUND The basis for progressive attenuation of the effects of organic nitrates during long-term therapy (nitrate tolerance) remains controversial; proposed mechanisms include impaired nitrate bioconversion resulting in decreased release of nitric oxide (NO) from nitrates and/or increased NO clearance through a reaction with incrementally generated superoxide (O(2)(-)). METHODS AND RESULT...
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PRECONDITIONING IS CHARACTERIZED by a remarkable ability to adapt to ischemic stress in a variety of organs (or tissues) with the highest clinical impact in the heart and brain (10, 24). Preconditioning can be induced by several interventions such as ischemia (blockade of blood supply), rapid pacing (increased oxygen demand), or administration of pharmacological agents (pharmacological precondi...
متن کاملNitroglycerin Tolerance in Caveolin-1 Deficient Mice
Nitrate tolerance developed after persistent nitroglycerin (GTN) exposure limits its clinical utility. Previously, we have shown that the vasodilatory action of GTN is dependent on endothelial nitric oxide synthase (eNOS/NOS3) activity. Caveolin-1 (Cav-1) is known to interact with NOS3 on the cytoplasmic side of cholesterol-enriched plasma membrane microdomains (caveolae) and to inhibit NOS3 ac...
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The long-term benefits of nitroglycerin (NTG) therapy are limited by the development of vascular tolerance and endothelial dysfunction in conductance coronary arteries. We have determined whether nitrate tolerance extends to NTG effects on myocardial O2 consumption (MV(O2)) and the ability of endogenous nitric oxide (NO) to modulate MV(O2) during exercise. In chronically instrumented dogs (n = ...
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ژورنال
عنوان ژورنال: JAMA: The Journal of the American Medical Association
سال: 1905
ISSN: 0098-7484
DOI: 10.1001/jama.1905.92500480026001f